Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff	2.05e-01	3.25e-01	1.65e-17	2.30e-01
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan	1.42e-02	2.86e-02	7.82e-03	2.30e-07
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	1.74e-01	4.44e-01	5.69e-17	1.95e-01
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan Exclusive	8.69e-03	5.07e-02	1.10e-02	1.39e-06
GS-Juan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	5.74e-01	7.72e-01	3.37e-01	1.19e-01
Overlap	Exclusives	2.90e-02	9.32e-02	9.69e-17	2.21e-02



Evaluating how well GS-Juan genes are linked to UKB-PD_combinedsex_unbal_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff	0.54	0.94	0.80	0.75	1.17
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan	0.88	1.74	2.53	2.14	4.74
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	0.54	0.75	0.63	0.65	1.27
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan Exclusive	0.87	2.18	2.44	2.04	4.47
GS-Juan Exclusive	Overlap	1.00	2.13	1.68	2.06	1.67
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	0.92	0.78	0.90	1.09	1.48
Overlap	Exclusives	0.57	1.09	0.77	1.36	2.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff	0.01	3.92	5.09	4.36	5.02
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan	0.00	1.25	1.30	2.18	3.89
GS-Juan Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	0.01	3.97	3.22	3.43	2.04
UKB-PD_combinedsex_unbal_mudiff Exclusive	GS-Juan Exclusive	0.00	1.32	1.30	1.65	1.43
GS-Juan Exclusive	Overlap	0.02	111.48	122.60	85.65	51.10
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	0.00	0.07	0.07	0.20	0.48
Overlap	Exclusives	0.01	5.36	3.73	2.68	6.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GS-Juan Exclusive	11	11	
UKB-PD_combinedsex_unbal_mudiff Exclusive	109	109	
Overlap	1	1