Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) GS-Juan Exclusive UKB-PD_male_bal_mudiff 8.01e-03 2.23e-01 1.94e-31 1.89e-01 UKB-PD_male_bal_mudiff Exclusive GS-Juan 4.87e-01 5.34e-01 5.77e-01 2.25e-04 GS-Juan Exclusive UKB-PD_male_bal_mudiff Exclusive 4.31e-03 1.78e-01 2.35e-32 1.69e-01 UKB-PD_male_bal_mudiff Exclusive GS-Juan Exclusive 3.17e-01 5.65e-01 3.96e-01 2.19e-04 GS-Juan Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 UKB-PD_male_bal_mudiff Exclusive Overlap 6.93e-01 8.51e-01 6.53e-01 5.35e-01 Overlap Exclusives 4.16e-05 2.03e-01 3.20e-29 2.25e-01 Evaluating how well GS-Juan genes are linked to UKB-PD_male_bal_mudiff genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) GS-Juan Exclusive UKB-PD_male_bal_mudiff 0.53 0.10 1.82 2.12 1.60 UKB-PD_male_bal_mudiff Exclusive GS-Juan 0.83 1.48 0.93 1.23 4.29 GS-Juan Exclusive UKB-PD_male_bal_mudiff Exclusive 0.53 -0.30 1.99 2.17 1.43 UKB-PD_male_bal_mudiff Exclusive GS-Juan Exclusive 0.83 1.41 1.21 1.29 4.32 GS-Juan Exclusive Overlap 1.00 2.62 1.70 1.86 1.66 UKB-PD_male_bal_mudiff Exclusive Overlap 0.73 -0.29 -0.18 -0.24 0.89 Overlap Exclusives 0.53 2.55 1.37 1.12 1.72 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) GS-Juan Exclusive UKB-PD_male_bal_mudiff 0.01 0.07 2.49 1.64 1.29 UKB-PD_male_bal_mudiff Exclusive GS-Juan 0.00 0.64 -3.96 0.42 5.76 GS-Juan Exclusive UKB-PD_male_bal_mudiff Exclusive 0.01 -0.43 1.36 0.97 0.44 UKB-PD_male_bal_mudiff Exclusive GS-Juan Exclusive 0.00 0.62 -4.48 0.47 0.76 GS-Juan Exclusive Overlap 0.02 279.75 121.27 21.25 100.92 UKB-PD_male_bal_mudiff Exclusive Overlap 0.00 -0.33 -0.36 -0.42 -0.09 Overlap Exclusives 0.01 3.49 3.47 1.46 2.85 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes GS-Juan Exclusive 11 11 UKB-PD_male_bal_mudiff Exclusive 190 189 KDM5D Overlap 1 1