Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff	6.16e-01	5.04e-01	4.37e-01	8.75e-01
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	2.02e-01	1.72e-01	3.77e-01	2.69e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	4.17e-01	5.48e-01	4.42e-01	7.33e-01
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	1.10e-01	1.20e-01	1.72e-01	7.50e-02
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	7.88e-01	7.01e-01	9.10e-01	8.17e-01
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	3.83e-01	2.28e-01	4.47e-01	4.47e-01
Overlap	Exclusives	2.68e-01	5.91e-01	1.81e-02	1.33e-01



Evaluating how well UKB-PD_combinedsex_bal_mudiff genes are linked to UKB-PD_combinedsex_unbal_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff	0.48	-1.21	-1.64	-1.31	-0.63
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.47	-1.67	-2.01	-1.95	-1.46
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	0.47	-1.91	-1.35	-1.69	-0.99
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.47	-1.90	-1.82	-1.90	-1.92
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.54	0.90	-0.09	0.17	0.58
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	0.52	0.24	-0.64	0.18	0.09
Overlap	Exclusives	0.52	1.12	1.27	0.66	1.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff	0.01	-0.29	-0.49	-0.39	-0.30
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.01	-0.66	-1.03	-0.99	-0.78
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_combinedsex_unbal_mudiff Exclusive	0.00	-0.82	-0.57	-0.60	-0.68
UKB-PD_combinedsex_unbal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.01	-0.73	-0.60	-0.69	-0.91
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.00	1.33	0.95	0.00	-0.07
UKB-PD_combinedsex_unbal_mudiff Exclusive	Overlap	0.00	-0.37	-0.61	-0.16	-0.56
Overlap	Exclusives	0.01	0.14	0.97	0.01	0.28

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-PD_combinedsex_bal_mudiff Exclusive	183	181	KDM5D;C17orf113
UKB-PD_combinedsex_unbal_mudiff Exclusive	88	88	
Overlap	22	22