Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff	3.12e-01	5.85e-01	3.48e-01	6.97e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex	1.63e-01	3.14e-01	4.42e-01	3.01e-01
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	7.14e-01	6.01e-01	6.74e-01	7.03e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex Exclusive	1.83e-01	2.43e-01	4.05e-01	4.46e-01
AMP-PD_combinedsex Exclusive	Overlap	6.24e-02	5.05e-02	4.66e-02	2.42e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	9.00e-01	8.73e-01	6.88e-01	9.36e-01
Overlap	Exclusives	7.34e-02	3.37e-02	1.44e-04	9.33e-02



Evaluating how well AMP-PD_combinedsex genes are linked to UKB-PD_combinedsex_bal_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff	0.52	1.65	1.15	1.78	0.92
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex	0.53	1.61	1.16	1.59	1.51
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.52	1.33	0.98	1.10	0.94
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex Exclusive	0.53	1.61	1.55	1.67	1.05
AMP-PD_combinedsex Exclusive	Overlap	0.65	1.91	1.91	2.11	1.11
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.52	0.44	0.43	1.04	0.06
Overlap	Exclusives	0.51	0.33	0.94	0.92	0.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff	0.01	1.52	3.84	2.98	2.50
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex	0.01	0.92	0.90	0.96	0.76
AMP-PD_combinedsex Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.01	2.10	4.33	1.83	2.84
UKB-PD_combinedsex_bal_mudiff Exclusive	AMP-PD_combinedsex Exclusive	0.01	1.13	1.25	0.79	0.42
AMP-PD_combinedsex Exclusive	Overlap	0.00	0.26	0.06	0.94	-0.11
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.00	-0.08	-0.24	-0.05	-0.18
Overlap	Exclusives	0.02	0.87	1.81	1.80	1.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
AMP-PD_combinedsex Exclusive	154	154	
UKB-PD_combinedsex_bal_mudiff Exclusive	153	150	CCDC7;SYT15;PRAG1
Overlap	5	5