Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female	7.76e-01	6.63e-01	2.51e-01	5.64e-01
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female	8.69e-01	4.40e-01	9.88e-01	4.09e-01
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female Exclusive	7.53e-01	7.51e-01	4.27e-01	7.04e-01
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female Exclusive	9.54e-01	5.07e-01	9.97e-01	4.97e-01
UKB-PD_mudiff_bal_female Exclusive	Overlap	9.22e-01	7.89e-01	9.80e-01	6.12e-01
AMP-PD_female Exclusive	Overlap	2.16e-01	1.41e-01	3.74e-01	4.62e-02
Overlap	Exclusives	1.90e-02	3.94e-01	1.23e-17	7.93e-01



Evaluating how well UKB-PD_mudiff_bal_female genes are linked to AMP-PD_female genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female	0.49	-0.41	-0.41	-0.63	-0.49
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female	0.48	-0.92	-0.63	-0.77	-0.89
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female Exclusive	0.50	-0.41	-0.17	-0.36	-0.11
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female Exclusive	0.49	-0.54	-0.39	-0.54	-0.49
UKB-PD_mudiff_bal_female Exclusive	Overlap	0.29	-0.70	-0.75	-0.45	-1.25
AMP-PD_female Exclusive	Overlap	0.13	-1.65	-1.86	-1.47	-2.08
Overlap	Exclusives	0.50	-0.77	-0.44	-0.18	0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female	0.01	-0.38	-0.27	-0.68	-0.37
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female	0.01	-0.32	0.40	-0.40	-0.34
UKB-PD_mudiff_bal_female Exclusive	AMP-PD_female Exclusive	0.01	-0.34	-0.08	-0.44	-0.21
AMP-PD_female Exclusive	UKB-PD_mudiff_bal_female Exclusive	0.01	-0.23	0.55	-0.27	-0.15
UKB-PD_mudiff_bal_female Exclusive	Overlap	0.00	-0.31	-0.42	-0.28	-0.41
AMP-PD_female Exclusive	Overlap	0.00	-0.25	-0.29	-0.26	-0.52
Overlap	Exclusives	0.01	-0.78	-0.56	-0.47	-0.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-PD_mudiff_bal_female Exclusive	155	152	SYT15;PRAG1;CCDC7
AMP-PD_female Exclusive	113	113	
Overlap	3	3