Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff	2.82e-01	7.09e-01	1.69e-01	7.95e-01
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	9.22e-01	9.37e-01	9.22e-01	9.17e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff Exclusive	4.69e-01	7.72e-01	4.90e-01	8.87e-01
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	9.22e-01	8.51e-01	9.78e-01	7.58e-01
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	4.69e-01	7.27e-01	3.01e-01	8.73e-01
UKB-PD_female_bal_mudiff Exclusive	Overlap	7.09e-01	5.20e-01	7.12e-01	2.35e-01
Overlap	Exclusives	2.28e-01	1.33e-01	2.70e-01	6.79e-02



Evaluating how well UKB-PD_combinedsex_bal_mudiff genes are linked to UKB-PD_female_bal_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff	0.51	1.27	0.79	0.94	0.51
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.50	-0.09	0.17	0.10	0.30
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff Exclusive	0.51	0.82	0.70	0.67	0.51
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.51	0.23	0.62	0.29	0.62
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.51	0.65	0.61	1.04	0.11
UKB-PD_female_bal_mudiff Exclusive	Overlap	0.46	-0.49	-0.60	-0.10	-0.94
Overlap	Exclusives	0.52	1.00	1.13	1.23	1.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff	0.01	0.28	0.91	0.01	-0.08
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.01	-0.02	0.89	0.04	0.22
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_female_bal_mudiff Exclusive	0.01	0.04	0.58	0.01	-0.07
UKB-PD_female_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.01	0.40	0.84	0.56	0.29
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.00	-0.58	0.39	-0.27	-0.34
UKB-PD_female_bal_mudiff Exclusive	Overlap	0.00	-0.13	1.87	0.07	0.38
Overlap	Exclusives	0.02	0.59	0.50	0.62	1.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-PD_combinedsex_bal_mudiff Exclusive	175	173	C17orf113;KDM5D
UKB-PD_female_bal_mudiff Exclusive	128	125	CCDC7;PRAG1;SYT15
Overlap	30	30