Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff	1.85e-01	5.29e-01	2.78e-01	6.02e-01
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	7.45e-02	5.36e-02	2.12e-01	5.09e-02
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff Exclusive	3.09e-02	7.36e-02	7.64e-02	2.78e-01
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	7.20e-02	4.20e-02	1.20e-01	4.00e-02
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	9.42e-01	5.74e-01	9.20e-01	8.33e-01
UKB-PD_male_bal_mudiff Exclusive	Overlap	5.67e-01	5.10e-01	6.51e-01	4.79e-01
Overlap	Exclusives	5.17e-01	7.02e-01	4.36e-01	4.25e-01



Evaluating how well UKB-PD_combinedsex_bal_mudiff genes are linked to UKB-PD_male_bal_mudiff genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff	0.52	1.55	1.34	1.24	1.00
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.54	2.18	2.14	2.42	2.12
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff Exclusive	0.54	2.76	1.93	1.98	1.29
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.55	2.44	2.48	2.24	1.86
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.48	-0.35	-1.13	-0.63	-0.66
UKB-PD_male_bal_mudiff Exclusive	Overlap	0.52	0.65	0.29	0.74	0.53
Overlap	Exclusives	0.50	0.62	0.44	0.38	0.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff	0.01	1.03	0.98	0.39	0.11
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff	0.01	0.97	1.19	1.09	0.73
UKB-PD_combinedsex_bal_mudiff Exclusive	UKB-PD_male_bal_mudiff Exclusive	0.01	2.04	1.34	0.96	0.27
UKB-PD_male_bal_mudiff Exclusive	UKB-PD_combinedsex_bal_mudiff Exclusive	0.01	1.03	0.51	0.81	0.19
UKB-PD_combinedsex_bal_mudiff Exclusive	Overlap	0.00	-0.37	-0.52	-0.46	-0.33
UKB-PD_male_bal_mudiff Exclusive	Overlap	0.00	-0.18	0.33	0.16	-0.05
Overlap	Exclusives	0.01	-0.04	-0.23	-0.27	-0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB-PD_combinedsex_bal_mudiff Exclusive	138	137	C17orf113
UKB-PD_male_bal_mudiff Exclusive	124	124	
Overlap	67	66	KDM5D