Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukbpd-combsex-bal Exclusive	ukbpd-bal-male	1.47e-01	6.22e-01	3.52e-01	7.18e-01
ukbpd-bal-male Exclusive	ukbpd-combsex-bal	1.09e-01	4.89e-02	1.56e-01	3.04e-02
ukbpd-combsex-bal Exclusive	ukbpd-bal-male Exclusive	3.57e-02	6.53e-02	5.88e-02	1.67e-01
ukbpd-bal-male Exclusive	ukbpd-combsex-bal Exclusive	7.39e-02	3.15e-02	1.00e-01	2.68e-02
ukbpd-combsex-bal Exclusive	Overlap	9.33e-01	4.97e-01	9.33e-01	9.39e-01
ukbpd-bal-male Exclusive	Overlap	5.49e-01	6.64e-01	5.79e-01	4.03e-01
Overlap	Exclusives	4.12e-01	7.27e-01	5.20e-01	4.39e-01



Evaluating how well ukbpd-combsex-bal genes are linked to ukbpd-bal-male genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-bal Exclusive	ukbpd-bal-male	0.52	1.61	0.90	1.04	0.69
ukbpd-bal-male Exclusive	ukbpd-combsex-bal	0.54	2.36	2.50	2.89	2.08
ukbpd-combsex-bal Exclusive	ukbpd-bal-male Exclusive	0.54	2.08	2.14	2.16	1.40
ukbpd-bal-male Exclusive	ukbpd-combsex-bal Exclusive	0.55	2.73	2.87	2.31	2.14
ukbpd-combsex-bal Exclusive	Overlap	0.48	-0.60	-1.09	-0.73	-0.42
ukbpd-bal-male Exclusive	Overlap	0.52	0.52	0.14	0.76	0.54
Overlap	Exclusives	0.50	0.45	0.26	0.39	0.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-bal Exclusive	ukbpd-bal-male	0.01	1.17	0.81	0.66	-0.13
ukbpd-bal-male Exclusive	ukbpd-combsex-bal	0.01	0.53	1.07	1.31	1.02
ukbpd-combsex-bal Exclusive	ukbpd-bal-male Exclusive	0.01	1.39	1.24	1.18	0.37
ukbpd-bal-male Exclusive	ukbpd-combsex-bal Exclusive	0.01	1.16	0.47	0.41	0.84
ukbpd-combsex-bal Exclusive	Overlap	0.00	-0.57	-0.58	-0.50	-0.49
ukbpd-bal-male Exclusive	Overlap	0.00	-0.04	0.07	-0.00	0.10
Overlap	Exclusives	0.01	-0.20	-0.24	-0.07	-0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukbpd-combsex-bal Exclusive	138	137	C17orf113
ukbpd-bal-male Exclusive	124	124	
Overlap	67	66	KDM5D