Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) combined_122 Exclusive female_AD_69 8.93e-02 1.04e-01 8.04e-03 5.10e-03 female_AD_69 Exclusive combined_122 9.33e-01 6.24e-01 9.00e-02 8.10e-02 combined_122 Exclusive female_AD_69 Exclusive 3.60e-01 4.06e-01 7.64e-02 4.44e-02 female_AD_69 Exclusive combined_122 Exclusive 6.46e-01 3.21e-01 9.30e-02 1.23e-02 combined_122 Exclusive Overlap 2.13e-02 1.02e-02 1.64e-03 9.49e-03 female_AD_69 Exclusive Overlap 7.09e-01 8.50e-01 9.88e-01 8.38e-01 Overlap Exclusives 8.53e-01 4.18e-01 3.41e-01 4.69e-02 Evaluating how well combined_122 genes are linked to female_AD_69 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) combined_122 Exclusive female_AD_69 0.59 2.67 2.23 2.89 2.50 female_AD_69 Exclusive combined_122 0.54 0.56 0.49 0.65 1.59 combined_122 Exclusive female_AD_69 Exclusive 0.57 1.20 0.98 0.86 1.86 female_AD_69 Exclusive combined_122 Exclusive 0.57 1.04 0.94 1.03 2.36 combined_122 Exclusive Overlap 0.61 2.79 2.52 2.62 2.56 female_AD_69 Exclusive Overlap 0.48 -0.66 -0.46 -0.38 -0.46 Overlap Exclusives 0.57 0.20 1.38 1.36 2.71 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) combined_122 Exclusive female_AD_69 0.00 1.18 0.21 1.61 0.66 female_AD_69 Exclusive combined_122 0.01 -0.39 -0.66 -0.24 0.28 combined_122 Exclusive female_AD_69 Exclusive 0.00 -0.07 -0.20 0.03 0.48 female_AD_69 Exclusive combined_122 Exclusive 0.01 -0.04 -0.01 0.12 0.79 combined_122 Exclusive Overlap 0.00 3.10 0.62 0.28 0.34 female_AD_69 Exclusive Overlap 0.00 -0.52 -1.16 -0.55 -0.58 Overlap Exclusives 0.01 0.53 1.61 0.87 1.73 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes combined_122 Exclusive 87 87 female_AD_69 Exclusive 35 34 RAB6D Overlap 35 34 RFPL2