Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
combined_122 Exclusive	female_AD_69	8.93e-02	1.04e-01	8.04e-03	5.10e-03
female_AD_69 Exclusive	combined_122	9.33e-01	6.24e-01	9.00e-02	8.10e-02
combined_122 Exclusive	female_AD_69 Exclusive	3.60e-01	4.06e-01	7.64e-02	4.44e-02
female_AD_69 Exclusive	combined_122 Exclusive	6.46e-01	3.21e-01	9.30e-02	1.23e-02
combined_122 Exclusive	Overlap	2.13e-02	1.02e-02	1.64e-03	9.49e-03
female_AD_69 Exclusive	Overlap	7.09e-01	8.50e-01	9.88e-01	8.38e-01
Overlap	Exclusives	8.53e-01	4.18e-01	3.41e-01	4.69e-02



Evaluating how well combined_122 genes are linked to female_AD_69 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
combined_122 Exclusive	female_AD_69	0.59	2.67	2.23	2.89	2.50
female_AD_69 Exclusive	combined_122	0.54	0.56	0.49	0.65	1.59
combined_122 Exclusive	female_AD_69 Exclusive	0.57	1.20	0.98	0.86	1.86
female_AD_69 Exclusive	combined_122 Exclusive	0.57	1.04	0.94	1.03	2.36
combined_122 Exclusive	Overlap	0.61	2.79	2.52	2.62	2.56
female_AD_69 Exclusive	Overlap	0.48	-0.66	-0.46	-0.38	-0.46
Overlap	Exclusives	0.57	0.20	1.38	1.36	2.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
combined_122 Exclusive	female_AD_69	0.00	1.18	0.21	1.61	0.66
female_AD_69 Exclusive	combined_122	0.01	-0.39	-0.66	-0.24	0.28
combined_122 Exclusive	female_AD_69 Exclusive	0.00	-0.07	-0.20	0.03	0.48
female_AD_69 Exclusive	combined_122 Exclusive	0.01	-0.04	-0.01	0.12	0.79
combined_122 Exclusive	Overlap	0.00	3.10	0.62	0.28	0.34
female_AD_69 Exclusive	Overlap	0.00	-0.52	-1.16	-0.55	-0.58
Overlap	Exclusives	0.01	0.53	1.61	0.87	1.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
combined_122 Exclusive	87	87	
female_AD_69 Exclusive	35	34	RAB6D
Overlap	35	34	RFPL2