Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) ukbpd-combsex-threeptfive Exclusive GS-Juan 8.07e-01 4.69e-01 8.65e-01 4.69e-02 GS-Juan Exclusive ukbpd-combsex-threeptfive 5.02e-01 8.48e-01 3.47e-09 3.81e-01 ukbpd-combsex-threeptfive Exclusive GS-Juan Exclusive 5.30e-01 5.70e-01 8.32e-01 1.58e-02 GS-Juan Exclusive ukbpd-combsex-threeptfive Exclusive 4.65e-01 8.01e-01 1.41e-08 6.30e-01 ukbpd-combsex-threeptfive Exclusive Overlap 2.57e-01 2.77e-01 2.38e-01 8.91e-01 GS-Juan Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 5.20e-03 2.60e-01 8.71e-14 2.07e-02 Evaluating how well ukbpd-combsex-threeptfive genes are linked to GS-Juan genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ukbpd-combsex-threeptfive Exclusive GS-Juan 0.71 0.02 -0.57 -0.03 2.56 GS-Juan Exclusive ukbpd-combsex-threeptfive 0.54 0.65 0.64 1.13 1.31 ukbpd-combsex-threeptfive Exclusive GS-Juan Exclusive 0.73 0.67 -0.20 0.26 2.63 GS-Juan Exclusive ukbpd-combsex-threeptfive Exclusive 0.53 0.43 0.75 1.16 0.96 ukbpd-combsex-threeptfive Exclusive Overlap 0.45 -1.45 -1.58 -1.59 -0.18 GS-Juan Exclusive Overlap 1.00 2.50 1.56 2.14 1.65 Overlap Exclusives 0.59 1.81 2.18 1.61 3.02 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) ukbpd-combsex-threeptfive Exclusive GS-Juan 0.00 0.07 -1.65 0.05 0.99 GS-Juan Exclusive ukbpd-combsex-threeptfive 0.00 0.77 1.61 0.94 0.40 ukbpd-combsex-threeptfive Exclusive GS-Juan Exclusive 0.00 0.92 -1.63 0.52 1.23 GS-Juan Exclusive ukbpd-combsex-threeptfive Exclusive 0.00 -0.36 -0.11 0.22 0.30 ukbpd-combsex-threeptfive Exclusive Overlap 0.00 -0.57 -0.55 -0.38 -0.18 GS-Juan Exclusive Overlap 0.02 172.27 117.13 70.92 85.39 Overlap Exclusives 0.01 4.85 4.67 2.87 4.98 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes ukbpd-combsex-threeptfive Exclusive 70 69 KDM5D GS-Juan Exclusive 11 11 Overlap 1 1