Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GS-Juan	8.07e-01	4.69e-01	8.65e-01	4.69e-02
GS-Juan Exclusive	ukbpd-combsex-threeptfive	5.02e-01	8.48e-01	3.47e-09	3.81e-01
ukbpd-combsex-threeptfive Exclusive	GS-Juan Exclusive	5.30e-01	5.70e-01	8.32e-01	1.58e-02
GS-Juan Exclusive	ukbpd-combsex-threeptfive Exclusive	4.65e-01	8.01e-01	1.41e-08	6.30e-01
ukbpd-combsex-threeptfive Exclusive	Overlap	2.57e-01	2.77e-01	2.38e-01	8.91e-01
GS-Juan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.20e-03	2.60e-01	8.71e-14	2.07e-02



Evaluating how well ukbpd-combsex-threeptfive genes are linked to GS-Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GS-Juan	0.71	0.02	-0.57	-0.03	2.56
GS-Juan Exclusive	ukbpd-combsex-threeptfive	0.54	0.65	0.64	1.13	1.31
ukbpd-combsex-threeptfive Exclusive	GS-Juan Exclusive	0.73	0.67	-0.20	0.26	2.63
GS-Juan Exclusive	ukbpd-combsex-threeptfive Exclusive	0.53	0.43	0.75	1.16	0.96
ukbpd-combsex-threeptfive Exclusive	Overlap	0.45	-1.45	-1.58	-1.59	-0.18
GS-Juan Exclusive	Overlap	1.00	2.50	1.56	2.14	1.65
Overlap	Exclusives	0.59	1.81	2.18	1.61	3.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GS-Juan	0.00	0.07	-1.65	0.05	0.99
GS-Juan Exclusive	ukbpd-combsex-threeptfive	0.00	0.77	1.61	0.94	0.40
ukbpd-combsex-threeptfive Exclusive	GS-Juan Exclusive	0.00	0.92	-1.63	0.52	1.23
GS-Juan Exclusive	ukbpd-combsex-threeptfive Exclusive	0.00	-0.36	-0.11	0.22	0.30
ukbpd-combsex-threeptfive Exclusive	Overlap	0.00	-0.57	-0.55	-0.38	-0.18
GS-Juan Exclusive	Overlap	0.02	172.27	117.13	70.92	85.39
Overlap	Exclusives	0.01	4.85	4.67	2.87	4.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukbpd-combsex-threeptfive Exclusive	70	69	KDM5D
GS-Juan Exclusive	11	11	
Overlap	1	1