Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	Singleton	3.13e-02	1.03e-01	7.16e-02	4.96e-01
Singleton Exclusive	ukbpd-combsex-threeptfive	1.71e-03	1.20e-01	4.40e-04	3.38e-01
ukbpd-combsex-threeptfive Exclusive	Singleton Exclusive	2.52e-02	8.88e-02	6.64e-02	4.02e-01
Singleton Exclusive	ukbpd-combsex-threeptfive Exclusive	2.36e-03	1.32e-01	3.17e-04	2.53e-01
ukbpd-combsex-threeptfive Exclusive	Overlap	5.35e-01	9.31e-01	5.54e-01	9.11e-01
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	4.21e-03	3.20e-03	3.49e-12	6.27e-04



Evaluating how well ukbpd-combsex-threeptfive genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	Singleton	0.59	-2.48	-2.35	-1.62	1.24
Singleton Exclusive	ukbpd-combsex-threeptfive	0.48	-1.89	-1.62	-0.81	-0.68
ukbpd-combsex-threeptfive Exclusive	Singleton Exclusive	0.58	-2.19	-2.15	-1.60	1.19
Singleton Exclusive	ukbpd-combsex-threeptfive Exclusive	0.47	-1.85	-1.63	-0.78	-0.87
ukbpd-combsex-threeptfive Exclusive	Overlap	0.60	-0.55	-0.38	-0.58	0.24
Singleton Exclusive	Overlap	1.00	2.03	2.06	1.88	1.73
Overlap	Exclusives	0.59	3.35	1.55	2.21	3.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	Singleton	0.00	-0.57	-1.22	-0.42	0.01
Singleton Exclusive	ukbpd-combsex-threeptfive	0.00	1.13	0.10	0.79	1.24
ukbpd-combsex-threeptfive Exclusive	Singleton Exclusive	0.00	-0.51	-1.00	-0.21	0.54
Singleton Exclusive	ukbpd-combsex-threeptfive Exclusive	0.00	-1.07	-0.80	-0.66	-0.67
ukbpd-combsex-threeptfive Exclusive	Overlap	0.00	-0.28	-0.62	-0.32	-0.11
Singleton Exclusive	Overlap	0.06	215.83	265.95	135.63	7.41
Overlap	Exclusives	0.01	10.72	9.47	7.49	10.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukbpd-combsex-threeptfive Exclusive	76	75	KDM5D
Singleton Exclusive	20	20	
Overlap	1	1