Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GSJuan	3.81e-01	4.96e-01	6.46e-01	1.12e-02
GSJuan Exclusive	ukbpd-combsex-threeptfive	2.24e-02	5.38e-01	1.98e-08	6.51e-01
ukbpd-combsex-threeptfive Exclusive	GSJuan Exclusive	5.05e-01	6.47e-01	7.82e-01	1.10e-02
GSJuan Exclusive	ukbpd-combsex-threeptfive Exclusive	1.75e-02	4.75e-01	1.79e-08	5.49e-01
ukbpd-combsex-threeptfive Exclusive	Overlap	4.95e-01	8.91e-01	5.15e-01	7.92e-01
GSJuan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.19e-02	2.02e-01	5.85e-12	6.41e-02



Evaluating how well ukbpd-combsex-threeptfive genes are linked to GSJuan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GSJuan	0.71	-0.67	-0.21	-0.16	2.75
GSJuan Exclusive	ukbpd-combsex-threeptfive	0.48	-1.59	-1.48	-0.64	-0.61
ukbpd-combsex-threeptfive Exclusive	GSJuan Exclusive	0.72	-0.68	-0.12	-0.10	2.53
GSJuan Exclusive	ukbpd-combsex-threeptfive Exclusive	0.48	-1.75	-1.95	-0.69	-0.71
ukbpd-combsex-threeptfive Exclusive	Overlap	0.60	-0.73	-0.20	-0.64	0.40
GSJuan Exclusive	Overlap	1.00	2.30	1.71	2.14	1.72
Overlap	Exclusives	0.55	2.04	0.21	1.16	1.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukbpd-combsex-threeptfive Exclusive	GSJuan	0.00	-0.47	-1.41	-0.33	0.59
GSJuan Exclusive	ukbpd-combsex-threeptfive	0.00	1.24	-0.05	0.21	0.16
ukbpd-combsex-threeptfive Exclusive	GSJuan Exclusive	0.00	-0.59	-1.37	-0.36	0.38
GSJuan Exclusive	ukbpd-combsex-threeptfive Exclusive	0.00	-0.67	-0.37	-0.36	-0.45
ukbpd-combsex-threeptfive Exclusive	Overlap	0.00	-0.45	-0.54	-0.41	-0.22
GSJuan Exclusive	Overlap	0.02	147.16	125.11	21.61	96.92
Overlap	Exclusives	0.01	6.30	5.24	4.04	4.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukbpd-combsex-threeptfive Exclusive	76	75	KDM5D
GSJuan Exclusive	11	11	
Overlap	1	1