Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	ukbpd-male-threeptfive	1.48e-01	7.49e-01	4.41e-04	3.36e-01
ukbpd-male-threeptfive Exclusive	Singleton	5.60e-01	2.83e-01	3.40e-01	6.46e-03
Singleton Exclusive	ukbpd-male-threeptfive Exclusive	5.84e-02	6.68e-01	5.80e-04	3.98e-01
ukbpd-male-threeptfive Exclusive	Singleton Exclusive	7.77e-01	2.71e-01	6.66e-01	6.77e-03
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-threeptfive Exclusive	Overlap	2.38e-01	2.38e-01	2.97e-01	9.70e-01
Overlap	Exclusives	3.10e-03	1.79e-02	8.15e-16	2.52e-03



Evaluating how well Singleton genes are linked to ukbpd-male-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-male-threeptfive	0.52	-0.13	0.22	0.26	0.70
ukbpd-male-threeptfive Exclusive	Singleton	0.67	0.23	-0.29	-0.05	2.77
Singleton Exclusive	ukbpd-male-threeptfive Exclusive	0.51	-0.68	0.09	0.22	0.40
ukbpd-male-threeptfive Exclusive	Singleton Exclusive	0.68	0.68	-0.04	0.43	2.83
Singleton Exclusive	Overlap	1.00	2.18	1.87	1.81	1.64
ukbpd-male-threeptfive Exclusive	Overlap	0.45	-1.24	-1.72	-1.26	-0.03
Overlap	Exclusives	0.63	3.64	3.62	2.19	4.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-male-threeptfive	0.00	0.42	3.02	0.37	0.61
ukbpd-male-threeptfive Exclusive	Singleton	0.00	-0.02	-1.16	-0.17	1.44
Singleton Exclusive	ukbpd-male-threeptfive Exclusive	0.00	-0.27	0.35	-0.09	-0.06
ukbpd-male-threeptfive Exclusive	Singleton Exclusive	0.00	0.56	-1.05	0.12	0.90
Singleton Exclusive	Overlap	0.06	313.04	217.02	150.14	293.89
ukbpd-male-threeptfive Exclusive	Overlap	0.00	-0.38	-0.63	-0.57	-0.36
Overlap	Exclusives	0.01	11.65	10.13	4.43	11.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	20	20	
ukbpd-male-threeptfive Exclusive	70	69	KDM5D
Overlap	1	1