Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	ukbpd-female-threeptfive	7.35e-01	5.93e-01	6.32e-07	5.99e-01
ukbpd-female-threeptfive Exclusive	Singleton	7.64e-01	8.87e-01	6.84e-01	1.03e-01
Singleton Exclusive	ukbpd-female-threeptfive Exclusive	7.27e-01	6.15e-01	6.18e-07	5.08e-01
ukbpd-female-threeptfive Exclusive	Singleton Exclusive	8.72e-01	7.62e-01	6.96e-01	6.96e-02
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-female-threeptfive Exclusive	Overlap	6.93e-01	9.11e-01	8.91e-01	7.13e-01
Overlap	Exclusives	6.20e-04	1.58e-04	5.60e-14	1.20e-05



Evaluating how well Singleton genes are linked to ukbpd-female-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-female-threeptfive	0.53	1.75	0.69	1.44	0.70
ukbpd-female-threeptfive Exclusive	Singleton	0.66	-0.41	-0.09	-0.24	2.11
Singleton Exclusive	ukbpd-female-threeptfive Exclusive	0.52	1.82	0.55	1.04	0.63
ukbpd-female-threeptfive Exclusive	Singleton Exclusive	0.66	-0.21	-0.03	-0.30	2.09
Singleton Exclusive	Overlap	1.00	2.43	1.69	1.92	1.87
ukbpd-female-threeptfive Exclusive	Overlap	0.70	-0.39	-0.47	-0.03	0.60
Overlap	Exclusives	0.62	5.34	2.82	3.05	4.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-female-threeptfive	0.00	1.34	1.69	1.72	1.12
ukbpd-female-threeptfive Exclusive	Singleton	0.00	-0.43	-0.12	-0.37	1.11
Singleton Exclusive	ukbpd-female-threeptfive Exclusive	0.00	0.11	0.08	-0.24	-0.21
ukbpd-female-threeptfive Exclusive	Singleton Exclusive	0.00	-0.22	-0.04	-0.31	0.29
Singleton Exclusive	Overlap	0.06	576.68	213.13	167.04	349.01
ukbpd-female-threeptfive Exclusive	Overlap	0.00	-0.44	-0.55	-0.28	-0.15
Overlap	Exclusives	0.01	11.87	9.41	4.35	13.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	20	20	
ukbpd-female-threeptfive Exclusive	69	69	
Overlap	1	1