Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-four	1.56e-02	2.14e-01	1.22e-03	4.03e-01
ukbpd-combsex-four Exclusive	Singleton	9.27e-02	5.88e-02	5.22e-02	2.08e-02
Singleton Exclusive	ukbpd-combsex-four Exclusive	1.22e-02	2.06e-01	1.90e-03	4.23e-01
ukbpd-combsex-four Exclusive	Singleton Exclusive	2.56e-02	4.38e-02	4.00e-02	1.50e-02
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-combsex-four Exclusive	Overlap	5.94e-01	3.56e-01	6.34e-01	3.76e-01
Overlap	Exclusives	1.26e-05	1.07e-05	3.69e-13	5.55e-07



Evaluating how well Singleton genes are linked to ukbpd-combsex-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-four	0.47	-1.75	-1.73	-0.56	-0.71
ukbpd-combsex-four Exclusive	Singleton	0.57	-2.03	-2.54	-1.83	1.09
Singleton Exclusive	ukbpd-combsex-four Exclusive	0.45	-1.85	-1.87	-0.97	-0.93
ukbpd-combsex-four Exclusive	Singleton Exclusive	0.56	-2.41	-2.79	-1.94	1.02
Singleton Exclusive	Overlap	1.00	2.07	1.85	2.00	1.63
ukbpd-combsex-four Exclusive	Overlap	0.78	0.57	0.83	0.66	1.08
Overlap	Exclusives	0.70	4.98	3.64	3.83	4.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-four	0.00	3.09	1.60	1.32	3.78
ukbpd-combsex-four Exclusive	Singleton	0.00	-1.07	-1.83	-0.96	-0.08
Singleton Exclusive	ukbpd-combsex-four Exclusive	0.00	-0.55	-0.22	-0.97	-0.88
ukbpd-combsex-four Exclusive	Singleton Exclusive	0.00	-1.14	-1.91	-1.09	-0.13
Singleton Exclusive	Overlap	0.06	324.24	234.01	201.85	423.24
ukbpd-combsex-four Exclusive	Overlap	0.00	-0.23	0.79	0.01	-0.02
Overlap	Exclusives	0.01	19.95	19.85	10.41	13.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	20	20	
ukbpd-combsex-four Exclusive	35	34	KDM5D
Overlap	1	1