Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GSJuan Exclusive	ukbpd-male-four	8.98e-01	3.27e-01	1.17e-05	2.43e-02
ukbpd-male-four Exclusive	GSJuan	2.80e-01	2.97e-01	7.78e-02	2.09e-03
GSJuan Exclusive	ukbpd-male-four Exclusive	9.25e-01	3.29e-01	1.67e-05	4.12e-02
ukbpd-male-four Exclusive	GSJuan Exclusive	9.98e-02	2.06e-01	3.57e-02	3.40e-04
GSJuan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-four Exclusive	Overlap	7.92e-02	3.56e-01	4.16e-01	8.32e-01
Overlap	Exclusives	4.34e-02	5.12e-02	9.58e-08	4.84e-04



Evaluating how well GSJuan genes are linked to ukbpd-male-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-male-four	0.66	1.26	2.19	2.56	3.02
ukbpd-male-four Exclusive	GSJuan	0.76	1.12	0.54	1.01	3.30
GSJuan Exclusive	ukbpd-male-four Exclusive	0.64	0.91	2.03	1.74	2.31
ukbpd-male-four Exclusive	GSJuan Exclusive	0.79	1.81	0.57	1.35	3.34
GSJuan Exclusive	Overlap	1.00	2.55	1.55	2.13	1.74
ukbpd-male-four Exclusive	Overlap	0.47	-1.53	-1.35	-1.51	-0.27
Overlap	Exclusives	0.70	2.06	2.91	1.76	4.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-male-four	0.00	1.60	5.55	0.27	1.23
ukbpd-male-four Exclusive	GSJuan	0.00	1.05	-0.59	0.80	4.43
GSJuan Exclusive	ukbpd-male-four Exclusive	0.00	-0.13	1.33	0.45	0.83
ukbpd-male-four Exclusive	GSJuan Exclusive	0.00	2.01	-0.48	0.86	2.90
GSJuan Exclusive	Overlap	0.02	83.40	113.48	107.22	29.89
ukbpd-male-four Exclusive	Overlap	0.00	-0.68	-0.36	-0.28	-0.22
Overlap	Exclusives	0.01	5.96	8.61	4.65	11.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GSJuan Exclusive	11	11	
ukbpd-male-four Exclusive	26	25	KDM5D
Overlap	1	1