Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	ukbpd-male-four	4.87e-01	1.28e-01	2.55e-03	1.21e-02
ukbpd-male-four Exclusive	Singleton	2.00e-02	3.43e-01	9.41e-03	1.04e-04
Singleton Exclusive	ukbpd-male-four Exclusive	7.83e-01	2.23e-01	3.22e-03	3.01e-02
ukbpd-male-four Exclusive	Singleton Exclusive	1.50e-02	1.90e-01	4.69e-03	6.12e-05
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-four Exclusive	Overlap	9.90e-02	3.96e-01	3.37e-01	9.11e-01
Overlap	Exclusives	6.44e-05	5.14e-05	1.22e-09	4.39e-07



Evaluating how well Singleton genes are linked to ukbpd-male-four genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-male-four	0.66	1.86	3.03	2.51	2.97
ukbpd-male-four Exclusive	Singleton	0.77	2.77	2.17	1.52	4.70
Singleton Exclusive	ukbpd-male-four Exclusive	0.65	1.43	2.77	1.93	2.45
ukbpd-male-four Exclusive	Singleton Exclusive	0.79	3.03	2.15	2.17	5.02
Singleton Exclusive	Overlap	1.00	2.07	1.68	1.92	1.69
ukbpd-male-four Exclusive	Overlap	0.47	-1.48	-1.28	-1.53	-0.13
Overlap	Exclusives	0.75	2.96	3.81	2.53	6.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-male-four	0.01	7.71	13.38	7.45	9.47
ukbpd-male-four Exclusive	Singleton	0.00	3.06	0.61	1.36	3.77
Singleton Exclusive	ukbpd-male-four Exclusive	0.00	1.50	2.76	1.69	2.69
ukbpd-male-four Exclusive	Singleton Exclusive	0.00	2.97	0.67	1.91	1.64
Singleton Exclusive	Overlap	0.06	511.20	235.41	133.13	179.95
ukbpd-male-four Exclusive	Overlap	0.00	-0.63	-0.38	-0.35	-0.31
Overlap	Exclusives	0.01	12.54	17.19	9.05	22.80

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	20	20	
ukbpd-male-four Exclusive	26	25	KDM5D
Overlap	1	1