Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GSJuan Exclusive	ukbpd-combsex-fourptfive	7.46e-01	8.17e-01	2.41e-02	9.26e-01
ukbpd-combsex-fourptfive Exclusive	GSJuan	8.98e-01	9.83e-01	8.91e-01	2.11e-02
GSJuan Exclusive	ukbpd-combsex-fourptfive Exclusive	5.31e-01	7.03e-01	3.00e-02	9.96e-01
ukbpd-combsex-fourptfive Exclusive	GSJuan Exclusive	8.05e-01	6.82e-01	9.78e-01	1.78e-02
GSJuan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-combsex-fourptfive Exclusive	Overlap	2.77e-01	4.16e-01	3.56e-01	3.17e-01
Overlap	Exclusives	9.25e-04	8.88e-04	1.10e-06	4.19e-04



Evaluating how well GSJuan genes are linked to ukbpd-combsex-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-combsex-fourptfive	0.54	-0.17	-1.08	0.22	0.62
ukbpd-combsex-fourptfive Exclusive	GSJuan	0.70	-1.05	-0.44	-0.53	2.40
GSJuan Exclusive	ukbpd-combsex-fourptfive Exclusive	0.51	-0.74	-1.38	-0.03	0.13
ukbpd-combsex-fourptfive Exclusive	GSJuan Exclusive	0.69	-1.12	-1.04	-0.66	2.05
GSJuan Exclusive	Overlap	1.00	2.65	1.85	1.98	1.73
ukbpd-combsex-fourptfive Exclusive	Overlap	0.83	1.28	1.03	0.87	1.14
Overlap	Exclusives	0.73	2.92	2.50	2.55	4.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-combsex-fourptfive	0.00	4.54	3.07	3.15	0.53
ukbpd-combsex-fourptfive Exclusive	GSJuan	0.00	-0.51	-0.81	-0.42	0.08
GSJuan Exclusive	ukbpd-combsex-fourptfive Exclusive	0.00	-0.61	-0.49	-0.19	-0.18
ukbpd-combsex-fourptfive Exclusive	GSJuan Exclusive	0.00	-0.59	-1.21	-0.49	0.31
GSJuan Exclusive	Overlap	0.02	258.03	130.48	40.93	54.55
ukbpd-combsex-fourptfive Exclusive	Overlap	0.00	0.83	0.91	-0.05	-0.01
Overlap	Exclusives	0.01	15.72	17.51	8.90	1.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GSJuan Exclusive	11	11	
ukbpd-combsex-fourptfive Exclusive	17	16	KDM5D
Overlap	1	1