Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-fourptfive	4.43e-01	7.65e-01	1.54e-01	6.85e-01
ukbpd-combsex-fourptfive Exclusive	Singleton	4.52e-01	4.46e-01	8.76e-01	7.19e-03
Singleton Exclusive	ukbpd-combsex-fourptfive Exclusive	2.46e-01	5.44e-01	1.41e-01	9.24e-01
ukbpd-combsex-fourptfive Exclusive	Singleton Exclusive	4.18e-01	6.28e-01	9.80e-01	1.46e-02
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-combsex-fourptfive Exclusive	Overlap	3.96e-01	3.56e-01	3.96e-01	2.77e-01
Overlap	Exclusives	1.40e-08	2.32e-08	6.38e-10	1.64e-09



Evaluating how well Singleton genes are linked to ukbpd-combsex-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-fourptfive	0.54	0.06	-0.72	0.46	0.65
ukbpd-combsex-fourptfive Exclusive	Singleton	0.65	-1.36	-1.25	-0.99	2.28
Singleton Exclusive	ukbpd-combsex-fourptfive Exclusive	0.52	-0.68	-1.20	-0.02	0.27
ukbpd-combsex-fourptfive Exclusive	Singleton Exclusive	0.64	-1.46	-1.43	-1.23	1.78
Singleton Exclusive	Overlap	1.00	2.60	2.12	1.81	1.64
ukbpd-combsex-fourptfive Exclusive	Overlap	0.83	1.00	1.09	0.82	1.29
Overlap	Exclusives	0.78	4.22	4.88	3.88	5.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Singleton Exclusive	ukbpd-combsex-fourptfive	0.00	3.46	9.24	6.71	6.16
ukbpd-combsex-fourptfive Exclusive	Singleton	0.00	-0.82	-0.85	-0.68	0.48
Singleton Exclusive	ukbpd-combsex-fourptfive Exclusive	0.00	-0.56	-0.68	-0.40	-0.20
ukbpd-combsex-fourptfive Exclusive	Singleton Exclusive	0.00	-0.77	-1.05	-0.73	0.48
Singleton Exclusive	Overlap	0.06	710.35	281.10	201.61	41.77
ukbpd-combsex-fourptfive Exclusive	Overlap	0.00	0.03	1.03	-0.02	0.36
Overlap	Exclusives	0.02	24.12	34.81	13.51	16.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Singleton Exclusive	20	20	
ukbpd-combsex-fourptfive Exclusive	17	16	KDM5D
Overlap	1	1