Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma_diff Exclusive	50_tier1and2_GS	2.14e-09	3.56e-12	2.94e-17	1.14e-23
50_tier1and2_GS Exclusive	122_sigma_diff	2.23e-03	1.05e-02	1.37e-06	3.88e-05
122_sigma_diff Exclusive	50_tier1and2_GS Exclusive	1.26e-08	5.68e-11	8.08e-15	7.48e-22
50_tier1and2_GS Exclusive	122_sigma_diff Exclusive	2.14e-02	1.74e-02	2.45e-05	2.30e-04
122_sigma_diff Exclusive	Overlap	7.20e-04	1.43e-03	1.75e-05	1.27e-06
50_tier1and2_GS Exclusive	Overlap	1.49e-08	7.20e-04	5.90e-09	1.06e-06
Overlap	Exclusives	6.16e-10	3.49e-09	2.24e-17	8.17e-11



Evaluating how well 122_sigma_diff genes are linked to 50_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	50_tier1and2_GS	0.91	6.03	9.19	5.70	8.63
50_tier1and2_GS Exclusive	122_sigma_diff	0.63	3.51	3.26	4.22	5.09
122_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.90	4.63	8.65	4.36	10.51
50_tier1and2_GS Exclusive	122_sigma_diff Exclusive	0.62	4.66	3.25	4.25	4.49
122_sigma_diff Exclusive	Overlap	0.98	3.08	3.30	3.39	4.02
50_tier1and2_GS Exclusive	Overlap	0.99	3.42	4.01	3.49	3.70
Overlap	Exclusives	0.68	4.50	6.44	3.74	8.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	50_tier1and2_GS	0.03	14.28	25.16	22.27	26.69
50_tier1and2_GS Exclusive	122_sigma_diff	0.03	29.47	30.38	17.73	40.43
122_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.02	8.52	25.64	8.61	25.35
50_tier1and2_GS Exclusive	122_sigma_diff Exclusive	0.02	21.27	17.08	22.34	21.04
122_sigma_diff Exclusive	Overlap	0.01	13.64	27.09	32.21	2.33
50_tier1and2_GS Exclusive	Overlap	0.12	253.22	170.96	298.78	530.60
Overlap	Exclusives	0.10	43.38	111.52	69.19	146.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma_diff Exclusive	113	111	;RFPL2
50_tier1and2_GS Exclusive	45	45	
Overlap	5	5