Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma_diff Exclusive	25_tier1and2_GS	1.58e-17	2.96e-17	6.69e-21	5.37e-29
25_tier1and2_GS Exclusive	122_sigma_diff	1.70e-02	8.72e-04	1.04e-10	5.57e-07
122_sigma_diff Exclusive	25_tier1and2_GS Exclusive	1.75e-13	3.57e-14	1.04e-16	1.70e-22
25_tier1and2_GS Exclusive	122_sigma_diff Exclusive	2.99e-02	1.79e-03	2.74e-10	4.24e-06
122_sigma_diff Exclusive	Overlap	2.60e-04	1.50e-03	1.75e-05	3.25e-06
25_tier1and2_GS Exclusive	Overlap	2.51e-07	7.20e-04	3.26e-08	1.27e-06
Overlap	Exclusives	2.82e-05	1.97e-04	2.89e-13	3.16e-05



Evaluating how well 122_sigma_diff genes are linked to 25_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	25_tier1and2_GS	0.98	6.02	7.72	4.48	7.66
25_tier1and2_GS Exclusive	122_sigma_diff	0.64	5.16	4.04	5.15	5.71
122_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.98	4.84	7.26	4.70	7.86
25_tier1and2_GS Exclusive	122_sigma_diff Exclusive	0.63	4.45	4.03	4.69	5.40
122_sigma_diff Exclusive	Overlap	0.98	3.07	3.53	3.32	3.25
25_tier1and2_GS Exclusive	Overlap	0.99	3.69	2.99	3.36	3.72
Overlap	Exclusives	0.64	4.44	4.49	2.78	5.96

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	25_tier1and2_GS	0.04	23.94	32.58	31.12	88.69
25_tier1and2_GS Exclusive	122_sigma_diff	0.03	35.99	25.25	31.76	34.44
122_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.03	16.31	18.07	32.63	72.62
25_tier1and2_GS Exclusive	122_sigma_diff Exclusive	0.02	21.13	20.53	21.64	23.70
122_sigma_diff Exclusive	Overlap	0.01	28.00	23.32	50.52	24.45
25_tier1and2_GS Exclusive	Overlap	0.08	278.37	132.43	266.45	120.47
Overlap	Exclusives	0.06	82.48	72.36	44.41	88.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma_diff Exclusive	113	111	;RFPL2
25_tier1and2_GS Exclusive	20	20	
Overlap	5	5