Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GSJuan Exclusive	ukbpd-female-fourptfive	2.75e-01	9.90e-01	6.73e-03	9.03e-01
ukbpd-female-fourptfive Exclusive	GSJuan	4.96e-01	1.16e-01	7.85e-01	1.09e-03
GSJuan Exclusive	ukbpd-female-fourptfive Exclusive	3.25e-01	9.16e-01	4.11e-03	9.52e-01
ukbpd-female-fourptfive Exclusive	GSJuan Exclusive	7.72e-01	1.68e-01	7.72e-01	8.69e-03
GSJuan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-female-fourptfive Exclusive	Overlap	9.50e-01	8.12e-01	7.13e-01	5.15e-01
Overlap	Exclusives	3.64e-03	2.08e-03	5.98e-06	1.20e-04



Evaluating how well GSJuan genes are linked to ukbpd-female-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-female-fourptfive	0.53	-0.35	-0.41	-0.01	0.31
ukbpd-female-fourptfive Exclusive	GSJuan	0.72	-0.01	-0.32	-0.17	2.77
GSJuan Exclusive	ukbpd-female-fourptfive Exclusive	0.50	-0.88	-0.70	-0.31	0.01
ukbpd-female-fourptfive Exclusive	GSJuan Exclusive	0.71	-0.01	-0.26	-0.05	2.25
GSJuan Exclusive	Overlap	1.00	2.59	1.70	2.41	1.73
ukbpd-female-fourptfive Exclusive	Overlap	0.77	-0.00	0.12	0.25	0.97
Overlap	Exclusives	0.71	2.98	2.65	2.51	3.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-female-fourptfive	0.00	2.23	2.31	2.09	3.36
ukbpd-female-fourptfive Exclusive	GSJuan	0.00	-0.33	-0.61	-0.39	0.73
GSJuan Exclusive	ukbpd-female-fourptfive Exclusive	0.00	-0.58	-0.27	-0.16	-0.16
ukbpd-female-fourptfive Exclusive	GSJuan Exclusive	0.00	-0.33	-0.56	-0.35	1.01
GSJuan Exclusive	Overlap	0.02	103.75	119.91	88.97	40.66
ukbpd-female-fourptfive Exclusive	Overlap	0.00	-0.42	-0.43	-0.25	-0.13
Overlap	Exclusives	0.01	9.56	14.66	7.42	6.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GSJuan Exclusive	11	11	
ukbpd-female-fourptfive Exclusive	18	18	
Overlap	1	1