Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
singleton Exclusive	ukbpd-female-fourptfive	7.27e-01	8.99e-01	9.54e-03	4.87e-01
ukbpd-female-fourptfive Exclusive	singleton	5.24e-01	5.78e-01	2.66e-01	2.54e-04
singleton Exclusive	ukbpd-female-fourptfive Exclusive	5.33e-01	7.89e-01	1.04e-02	3.65e-01
ukbpd-female-fourptfive Exclusive	singleton Exclusive	3.68e-01	7.30e-01	6.09e-01	1.06e-03
singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-female-fourptfive Exclusive	Overlap	9.90e-01	6.53e-01	7.33e-01	5.74e-01
Overlap	Exclusives	2.26e-07	9.81e-08	5.56e-11	1.30e-10



Evaluating how well singleton genes are linked to ukbpd-female-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singleton Exclusive	ukbpd-female-fourptfive	0.56	0.33	0.08	0.72	0.64
ukbpd-female-fourptfive Exclusive	singleton	0.69	-0.04	0.16	0.10	3.35
singleton Exclusive	ukbpd-female-fourptfive Exclusive	0.53	-0.04	-0.03	0.25	0.67
ukbpd-female-fourptfive Exclusive	singleton Exclusive	0.69	0.18	-0.01	-0.13	3.12
singleton Exclusive	Overlap	1.00	2.61	1.73	1.98	1.64
ukbpd-female-fourptfive Exclusive	Overlap	0.77	-0.08	0.30	0.28	0.76
Overlap	Exclusives	0.77	3.34	4.41	2.81	6.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
singleton Exclusive	ukbpd-female-fourptfive	0.00	7.81	2.42	7.68	4.08
ukbpd-female-fourptfive Exclusive	singleton	0.00	-0.36	-0.28	-0.24	0.14
singleton Exclusive	ukbpd-female-fourptfive Exclusive	0.00	-0.15	-0.12	-0.13	-0.09
ukbpd-female-fourptfive Exclusive	singleton Exclusive	0.00	-0.24	-0.39	-0.41	0.75
singleton Exclusive	Overlap	0.06	581.19	200.76	299.49	44.24
ukbpd-female-fourptfive Exclusive	Overlap	0.00	-0.34	-0.31	-0.27	-0.18
Overlap	Exclusives	0.01	14.14	26.32	10.98	17.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
singleton Exclusive	20	20	
ukbpd-female-fourptfive Exclusive	18	18	
Overlap	1	1