Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GSJuan Exclusive	ukbpd-male-fourptfive	4.01e-01	1.99e-01	3.09e-04	1.34e-03
ukbpd-male-fourptfive Exclusive	GSJuan	1.35e-01	7.38e-01	3.95e-03	1.01e-03
GSJuan Exclusive	ukbpd-male-fourptfive Exclusive	8.73e-01	2.47e-01	9.37e-04	1.71e-03
ukbpd-male-fourptfive Exclusive	GSJuan Exclusive	5.07e-02	6.31e-01	3.00e-03	4.92e-04
GSJuan Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
ukbpd-male-fourptfive Exclusive	Overlap	2.57e-01	3.76e-01	7.72e-01	6.73e-01
Overlap	Exclusives	1.54e-04	1.17e-04	8.15e-05	4.42e-05



Evaluating how well GSJuan genes are linked to ukbpd-male-fourptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-male-fourptfive	0.85	2.77	3.34	3.76	3.24
ukbpd-male-fourptfive Exclusive	GSJuan	0.82	1.14	0.76	1.14	3.56
GSJuan Exclusive	ukbpd-male-fourptfive Exclusive	0.83	1.51	2.47	3.22	2.72
ukbpd-male-fourptfive Exclusive	GSJuan Exclusive	0.84	1.87	0.97	1.17	3.87
GSJuan Exclusive	Overlap	1.00	2.76	1.64	2.27	1.89
ukbpd-male-fourptfive Exclusive	Overlap	0.63	-1.04	-0.85	-1.68	0.50
Overlap	Exclusives	0.81	1.18	3.24	1.51	4.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GSJuan Exclusive	ukbpd-male-fourptfive	0.00	13.76	20.03	19.09	16.69
ukbpd-male-fourptfive Exclusive	GSJuan	0.00	4.58	1.91	2.89	3.92
GSJuan Exclusive	ukbpd-male-fourptfive Exclusive	0.00	0.29	2.24	3.17	3.16
ukbpd-male-fourptfive Exclusive	GSJuan Exclusive	0.00	7.21	1.79	2.67	6.19
GSJuan Exclusive	Overlap	0.02	297.84	113.68	126.58	104.55
ukbpd-male-fourptfive Exclusive	Overlap	0.00	-0.72	-0.79	-0.48	-0.17
Overlap	Exclusives	0.01	14.12	28.37	8.69	23.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GSJuan Exclusive	11	11	
ukbpd-male-fourptfive Exclusive	7	6	KDM5D
Overlap	1	1