Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma_diff Exclusive	25_tier1and2_GS	4.77e-07	3.07e-06	2.09e-08	9.43e-13
25_tier1and2_GS Exclusive	82_male_sigma_diff	1.79e-01	2.79e-02	1.20e-05	2.66e-03
82_male_sigma_diff Exclusive	25_tier1and2_GS Exclusive	3.86e-06	1.15e-05	4.51e-07	1.04e-10
25_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	7.45e-01	6.03e-02	6.21e-05	3.08e-02
82_male_sigma_diff Exclusive	Overlap	1.44e-01	2.02e-01	5.53e-02	1.61e-02
25_tier1and2_GS Exclusive	Overlap	1.28e-07	8.41e-03	2.30e-07	3.74e-05
Overlap	Exclusives	1.07e-03	4.28e-04	4.43e-13	1.71e-05



Evaluating how well 82_male_sigma_diff genes are linked to 25_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	25_tier1and2_GS	0.92	3.87	6.54	4.08	7.62
25_tier1and2_GS Exclusive	82_male_sigma_diff	0.59	2.81	2.50	3.28	3.23
82_male_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.92	4.02	6.06	3.97	5.90
25_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.57	1.67	2.14	2.34	1.82
82_male_sigma_diff Exclusive	Overlap	0.90	2.27	2.04	2.32	2.58
25_tier1and2_GS Exclusive	Overlap	0.99	4.02	2.82	3.34	3.57
Overlap	Exclusives	0.65	3.11	5.32	3.01	4.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	25_tier1and2_GS	0.01	9.15	12.90	11.31	2.74
25_tier1and2_GS Exclusive	82_male_sigma_diff	0.03	37.45	33.00	46.41	42.28
82_male_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.01	11.84	13.70	11.98	11.01
25_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.02	24.22	23.90	10.84	16.74
82_male_sigma_diff Exclusive	Overlap	0.00	4.64	5.12	4.48	1.72
25_tier1and2_GS Exclusive	Overlap	0.07	299.54	119.91	276.68	22.90
Overlap	Exclusives	0.06	54.86	99.09	29.52	87.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma_diff Exclusive	76	75	
25_tier1and2_GS Exclusive	21	21	
Overlap	4	4