Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	6.37e-04	2.74e-04	4.33e-06	6.87e-12
50_tier1and2_GS Exclusive	82_male_sigma_diff	1.91e-01	1.42e-01	3.65e-03	3.62e-02
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	1.33e-03	7.57e-04	2.72e-05	1.71e-10
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	4.11e-01	2.63e-01	1.65e-02	1.04e-01
82_male_sigma_diff Exclusive	Overlap	8.62e-02	1.97e-01	8.15e-02	9.45e-03
50_tier1and2_GS Exclusive	Overlap	6.04e-07	8.41e-03	2.74e-08	7.09e-06
Overlap	Exclusives	3.18e-09	1.77e-10	6.48e-20	5.93e-12



Evaluating how well 82_male_sigma_diff genes are linked to 50_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	0.81	2.88	6.16	3.71	7.53
50_tier1and2_GS Exclusive	82_male_sigma_diff	0.58	1.61	1.83	2.15	2.08
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.80	3.15	6.10	3.09	6.94
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.55	0.78	1.29	1.42	1.57
82_male_sigma_diff Exclusive	Overlap	0.90	2.66	1.93	2.29	3.70
50_tier1and2_GS Exclusive	Overlap	0.99	3.54	2.77	3.14	3.68
Overlap	Exclusives	0.70	4.00	7.24	3.93	9.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	0.01	6.47	10.61	7.05	4.24
50_tier1and2_GS Exclusive	82_male_sigma_diff	0.03	45.46	45.28	19.37	41.05
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.01	6.55	10.22	5.99	12.62
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.02	11.85	23.87	8.93	26.37
82_male_sigma_diff Exclusive	Overlap	0.00	5.10	4.23	5.65	1.86
50_tier1and2_GS Exclusive	Overlap	0.12	321.27	102.90	394.69	312.74
Overlap	Exclusives	0.10	62.12	148.46	72.97	186.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma_diff Exclusive	76	75	
50_tier1and2_GS Exclusive	46	46	
Overlap	4	4