Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	1.37e-06	2.67e-08	9.50e-09	6.27e-11
25_tier1and2_GS Exclusive	69_female_sigma_diff	4.31e-01	5.29e-01	4.48e-03	1.51e-01
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	3.02e-06	4.68e-08	3.18e-07	4.09e-09
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	6.70e-01	8.39e-01	4.97e-03	2.07e-01
69_female_sigma_diff Exclusive	Overlap	5.86e-02	5.92e-01	1.87e-02	2.07e-03
25_tier1and2_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.57e-04	1.07e-04	4.94e-12	6.53e-06



Evaluating how well 69_female_sigma_diff genes are linked to 25_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	0.88	1.94	5.84	3.47	7.37
25_tier1and2_GS Exclusive	69_female_sigma_diff	0.55	2.08	1.16	1.50	1.54
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.87	2.34	5.98	3.38	6.21
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.54	1.53	0.48	1.19	1.09
69_female_sigma_diff Exclusive	Overlap	0.97	1.40	1.71	1.97	2.47
25_tier1and2_GS Exclusive	Overlap	1.00	2.29	1.48	2.44	2.68
Overlap	Exclusives	0.66	3.13	4.48	2.86	5.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	0.01	2.25	18.08	6.66	13.88
25_tier1and2_GS Exclusive	69_female_sigma_diff	0.02	37.53	17.38	27.60	29.93
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.01	4.76	23.31	7.49	13.32
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.02	29.35	12.43	25.23	29.11
69_female_sigma_diff Exclusive	Overlap	0.00	0.64	2.50	2.59	8.28
25_tier1and2_GS Exclusive	Overlap	0.06	124.99	48.01	279.33	375.73
Overlap	Exclusives	0.04	20.56	47.23	28.71	62.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma_diff Exclusive	65	62	;RFPL2;RAB6D
25_tier1and2_GS Exclusive	23	23	
Overlap	2	2