Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma_diff Exclusive	50_tier1and2_GS	4.35e-05	4.46e-06	5.33e-06	1.56e-10
50_tier1and2_GS Exclusive	69_female_sigma_diff	4.55e-01	6.09e-01	4.64e-02	3.49e-01
69_female_sigma_diff Exclusive	50_tier1and2_GS Exclusive	1.54e-04	1.18e-05	4.32e-05	2.63e-10
50_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	5.06e-01	6.95e-01	1.66e-01	6.29e-01
69_female_sigma_diff Exclusive	Overlap	1.18e-02	5.37e-01	1.18e-02	6.50e-03
50_tier1and2_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.62e-09	1.01e-10	4.67e-22	5.34e-13



Evaluating how well 69_female_sigma_diff genes are linked to 50_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	50_tier1and2_GS	0.80	2.09	5.72	3.20	8.16
50_tier1and2_GS Exclusive	69_female_sigma_diff	0.53	0.36	0.09	0.33	0.93
69_female_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.79	2.46	6.21	2.99	7.86
50_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.51	0.11	-0.16	0.18	0.51
69_female_sigma_diff Exclusive	Overlap	0.97	1.82	1.54	2.12	2.37
50_tier1and2_GS Exclusive	Overlap	1.00	2.20	2.03	2.75	2.61
Overlap	Exclusives	0.71	5.77	7.79	3.16	6.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	50_tier1and2_GS	0.01	3.43	14.50	6.45	12.96
50_tier1and2_GS Exclusive	69_female_sigma_diff	0.03	49.88	30.02	38.17	57.15
69_female_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.01	4.65	15.16	6.34	16.76
50_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.02	8.80	15.48	16.19	26.47
69_female_sigma_diff Exclusive	Overlap	0.00	2.87	2.51	5.60	0.50
50_tier1and2_GS Exclusive	Overlap	0.10	131.29	144.44	501.76	39.42
Overlap	Exclusives	0.07	54.05	100.24	35.59	46.50

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma_diff Exclusive	65	62	;RFPL2;RAB6D
50_tier1and2_GS Exclusive	48	48	
Overlap	2	2