Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	1.40e-06	2.14e-08	8.00e-09	5.12e-11
25_tier1and2_GS Exclusive	69_female_sigma_diff	4.22e-01	5.19e-01	1.88e-03	1.36e-01
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	3.41e-06	4.82e-08	6.23e-07	1.30e-09
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	6.33e-01	8.60e-01	4.47e-03	2.45e-01
69_female_sigma_diff Exclusive	Overlap	4.89e-02	5.55e-01	2.28e-02	8.97e-03
25_tier1and2_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.92e-04	5.50e-05	2.75e-12	4.22e-06



Evaluating how well 69_female_sigma_diff genes are linked to 25_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	0.88	2.02	5.49	3.29	7.04
25_tier1and2_GS Exclusive	69_female_sigma_diff	0.55	1.93	1.06	1.72	1.56
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.87	2.44	6.33	2.80	5.93
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.54	1.36	0.48	1.05	1.03
69_female_sigma_diff Exclusive	Overlap	0.97	1.28	1.91	2.01	2.36
25_tier1and2_GS Exclusive	Overlap	1.00	2.30	1.77	2.31	2.23
Overlap	Exclusives	0.66	3.13	5.26	2.75	5.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma_diff Exclusive	25_tier1and2_GS	0.01	2.75	17.90	10.78	18.92
25_tier1and2_GS Exclusive	69_female_sigma_diff	0.02	26.63	18.81	39.14	44.73
69_female_sigma_diff Exclusive	25_tier1and2_GS Exclusive	0.01	3.76	18.18	5.67	14.09
25_tier1and2_GS Exclusive	69_female_sigma_diff Exclusive	0.02	41.06	13.70	21.22	34.74
69_female_sigma_diff Exclusive	Overlap	0.00	1.55	3.02	5.80	1.34
25_tier1and2_GS Exclusive	Overlap	0.06	122.93	73.62	181.15	79.60
Overlap	Exclusives	0.04	12.77	64.40	39.95	71.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma_diff Exclusive	65	62	;RFPL2;RAB6D
25_tier1and2_GS Exclusive	23	23	
Overlap	2	2