Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	2.48e-04	4.48e-04	4.73e-06	1.26e-12
50_tier1and2_GS Exclusive	82_male_sigma_diff	1.52e-01	1.34e-01	2.14e-03	2.18e-02
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	1.91e-03	4.01e-04	1.08e-04	1.87e-10
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	5.36e-01	2.39e-01	1.58e-02	1.21e-01
82_male_sigma_diff Exclusive	Overlap	1.10e-01	2.02e-01	6.85e-02	7.47e-03
50_tier1and2_GS Exclusive	Overlap	2.50e-06	8.41e-03	9.14e-09	3.21e-05
Overlap	Exclusives	1.99e-09	2.79e-10	3.93e-18	2.09e-11



Evaluating how well 82_male_sigma_diff genes are linked to 50_tier1and2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	0.81	3.34	5.97	3.66	7.83
50_tier1and2_GS Exclusive	82_male_sigma_diff	0.58	1.54	1.75	2.50	2.32
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.80	3.31	4.96	3.33	6.67
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.55	0.95	0.99	1.39	1.63
82_male_sigma_diff Exclusive	Overlap	0.90	2.57	1.78	2.46	3.00
50_tier1and2_GS Exclusive	Overlap	0.99	3.12	3.10	2.90	3.45
Overlap	Exclusives	0.70	4.03	8.11	3.53	7.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	50_tier1and2_GS	0.01	6.87	10.26	6.05	4.27
50_tier1and2_GS Exclusive	82_male_sigma_diff	0.03	17.92	34.15	20.07	44.65
82_male_sigma_diff Exclusive	50_tier1and2_GS Exclusive	0.01	6.33	9.65	6.51	8.68
50_tier1and2_GS Exclusive	82_male_sigma_diff Exclusive	0.02	22.04	22.80	9.45	24.01
82_male_sigma_diff Exclusive	Overlap	0.00	5.04	4.02	4.16	6.88
50_tier1and2_GS Exclusive	Overlap	0.12	131.00	102.56	304.80	144.41
Overlap	Exclusives	0.10	59.14	144.70	57.35	139.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma_diff Exclusive	76	75	
50_tier1and2_GS Exclusive	46	46	
Overlap	4	4