Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
71 PD genes	Singleton	8.25e-01	4.39e-01	5.31e-01	3.17e-02
Singleton	71 PD genes	8.58e-01	9.59e-01	2.50e-04	1.97e-01



Evaluating how well 71 PD genes genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
71 PD genes	Singleton	0.65	-0.16	0.74	-0.31	2.05
Singleton	71 PD genes	0.45	0.64	0.44	0.25	-1.38

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
71 PD genes	Singleton	0.00	-0.55	-0.39	-0.66	0.09
Singleton	71 PD genes	0.00	0.10	-0.31	-0.45	-0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
71 PD genes	71	71	
Singleton	21	21