Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukb-ad-mu-three	ukbpd-combsex-threeptfive	1.84e-01	1.10e-01	1.02e-01	2.17e-01
ukbpd-combsex-threeptfive	ukb-ad-mu-three	1.63e-01	6.95e-02	1.43e-01	8.22e-01



Evaluating how well ukb-ad-mu-three genes are linked to ukbpd-combsex-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukb-ad-mu-three	ukbpd-combsex-threeptfive	0.49	-0.48	-0.80	-0.43	-0.35
ukbpd-combsex-threeptfive	ukb-ad-mu-three	0.51	-1.26	-1.42	-1.43	0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukb-ad-mu-three	ukbpd-combsex-threeptfive	0.00	-1.18	-0.73	-1.04	-0.87
ukbpd-combsex-threeptfive	ukb-ad-mu-three	0.00	-1.00	-1.04	-0.97	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukb-ad-mu-three	79	78	C16orf86
ukbpd-combsex-threeptfive	77	76	KDM5D