Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive	8.30e-01	8.23e-01	9.68e-01	9.75e-01
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three	4.45e-01	2.79e-01	3.54e-01	7.25e-01
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive Exclusive	8.90e-01	9.48e-01	9.96e-01	9.59e-01
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three Exclusive	6.36e-01	3.01e-01	5.21e-01	8.79e-01
ukb-adbyproxy-mu-three Exclusive	Overlap	1.98e-02	1.19e-01	9.90e-02	4.55e-01
ukbpd-combsex-threeptfive Exclusive	Overlap	5.94e-01	5.94e-01	6.14e-01	4.16e-01
Overlap	Exclusives	1.42e-01	3.65e-01	2.82e-02	7.42e-01



Evaluating how well ukb-adbyproxy-mu-three genes are linked to ukbpd-combsex-threeptfive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive	0.48	-0.27	-0.76	-0.48	-0.38
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three	0.50	-1.25	-1.18	-1.81	-0.00
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive Exclusive	0.49	-0.27	-0.42	-0.45	-0.43
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three Exclusive	0.50	-0.92	-1.68	-1.30	0.17
ukb-adbyproxy-mu-three Exclusive	Overlap	0.16	-1.62	-1.60	-1.27	-0.94
ukbpd-combsex-threeptfive Exclusive	Overlap	0.21	-1.01	-0.87	-0.99	-1.12
Overlap	Exclusives	0.49	-1.33	-1.62	-1.74	-0.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive	0.00	-0.56	-0.40	-0.38	-0.45
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three	0.00	-0.20	-0.19	-0.58	0.26
ukb-adbyproxy-mu-three Exclusive	ukbpd-combsex-threeptfive Exclusive	0.00	-0.63	-0.27	-0.73	-0.50
ukbpd-combsex-threeptfive Exclusive	ukb-adbyproxy-mu-three Exclusive	0.00	-0.05	-0.45	-0.22	0.37
ukb-adbyproxy-mu-three Exclusive	Overlap	0.00	-0.22	-0.41	-0.24	-0.33
ukbpd-combsex-threeptfive Exclusive	Overlap	0.00	-0.26	-0.20	-0.38	-0.14
Overlap	Exclusives	0.01	-1.68	-1.69	-1.79	-0.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ukb-adbyproxy-mu-three Exclusive	82	81	SERPINA3
ukbpd-combsex-threeptfive Exclusive	76	75	KDM5D
Overlap	1	1