Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma_diff Exclusive	top25_from_93_diffusions	5.78e-16	2.81e-17	2.85e-20	7.40e-28
top25_from_93_diffusions Exclusive	122_sigma_diff	2.68e-03	5.66e-05	1.74e-12	3.83e-08
122_sigma_diff Exclusive	top25_from_93_diffusions Exclusive	1.31e-13	8.78e-16	7.12e-17	3.93e-24
top25_from_93_diffusions Exclusive	122_sigma_diff Exclusive	5.46e-03	1.76e-04	1.59e-12	6.55e-07
122_sigma_diff Exclusive	Overlap	1.94e-05	1.10e-02	2.30e-07	9.05e-07
top25_from_93_diffusions Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	9.09e-05	3.15e-04	5.67e-12	1.63e-05



Evaluating how well 122_sigma_diff genes are linked to top25_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	top25_from_93_diffusions	0.98	4.96	8.69	4.78	8.03
top25_from_93_diffusions Exclusive	122_sigma_diff	0.65	5.98	4.74	4.99	5.60
122_sigma_diff Exclusive	top25_from_93_diffusions Exclusive	0.98	4.96	7.45	4.89	7.65
top25_from_93_diffusions Exclusive	122_sigma_diff Exclusive	0.64	5.32	4.45	4.74	4.36
122_sigma_diff Exclusive	Overlap	0.99	2.32	2.94	3.11	3.13
top25_from_93_diffusions Exclusive	Overlap	1.00	3.27	3.09	3.05	3.18
Overlap	Exclusives	0.63	2.23	3.49	2.74	5.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma_diff Exclusive	top25_from_93_diffusions	0.04	22.78	48.64	36.50	77.15
top25_from_93_diffusions Exclusive	122_sigma_diff	0.03	37.19	26.77	32.85	38.66
122_sigma_diff Exclusive	top25_from_93_diffusions Exclusive	0.03	15.93	33.41	32.50	97.54
top25_from_93_diffusions Exclusive	122_sigma_diff Exclusive	0.02	21.86	16.57	24.50	19.22
122_sigma_diff Exclusive	Overlap	0.02	9.28	27.07	39.22	18.06
top25_from_93_diffusions Exclusive	Overlap	0.10	145.89	153.27	348.05	115.31
Overlap	Exclusives	0.06	42.33	79.55	36.79	92.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma_diff Exclusive	114	112	;RFPL2
top25_from_93_diffusions Exclusive	21	21	
Overlap	4	4