Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff Exclusive	top_50_from_93_diffusions	3.37e-14	2.77e-17	3.27e-22	6.22e-29
top_50_from_93_diffusions Exclusive	122_sigma-diff	3.23e-04	8.23e-04	4.00e-08	2.37e-06
122_sigma-diff Exclusive	top_50_from_93_diffusions Exclusive	1.86e-12	3.05e-16	1.15e-20	2.02e-25
top_50_from_93_diffusions Exclusive	122_sigma-diff Exclusive	7.64e-03	2.48e-03	2.11e-06	2.43e-05
122_sigma-diff Exclusive	Overlap	7.20e-04	2.11e-03	5.24e-05	6.34e-06
top_50_from_93_diffusions Exclusive	Overlap	1.88e-09	7.20e-04	3.44e-09	3.25e-06
Overlap	Exclusives	9.98e-10	3.77e-09	3.05e-18	5.85e-12



Evaluating how well 122_sigma-diff genes are linked to top_50_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	top_50_from_93_diffusions	0.92	5.28	11.97	5.50	10.55
top_50_from_93_diffusions Exclusive	122_sigma-diff	0.65	5.87	5.47	4.65	5.80
122_sigma-diff Exclusive	top_50_from_93_diffusions Exclusive	0.92	5.83	9.45	5.92	9.74
top_50_from_93_diffusions Exclusive	122_sigma-diff Exclusive	0.63	5.74	3.69	4.74	4.91
122_sigma-diff Exclusive	Overlap	0.98	2.82	3.51	2.94	3.82
top_50_from_93_diffusions Exclusive	Overlap	0.99	3.93	3.32	3.23	3.27
Overlap	Exclusives	0.69	4.92	9.12	3.82	7.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	top_50_from_93_diffusions	0.03	15.49	42.05	24.51	46.02
top_50_from_93_diffusions Exclusive	122_sigma-diff	0.04	47.25	35.46	34.06	43.22
122_sigma-diff Exclusive	top_50_from_93_diffusions Exclusive	0.02	11.64	28.73	21.94	44.01
top_50_from_93_diffusions Exclusive	122_sigma-diff Exclusive	0.02	21.32	17.89	12.45	24.44
122_sigma-diff Exclusive	Overlap	0.01	14.56	23.97	26.42	25.95
top_50_from_93_diffusions Exclusive	Overlap	0.13	616.13	173.81	305.81	499.28
Overlap	Exclusives	0.10	47.59	156.27	76.20	130.37

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff Exclusive	113	111	;RFPL2
top_50_from_93_diffusions Exclusive	45	45	
Overlap	5	5