Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff	bottom_50_from_93_diffusions	8.80e-01	9.16e-01	8.46e-01	5.76e-01
bottom_50_from_93_diffusions	122_sigma-diff	6.96e-02	2.24e-01	2.88e-01	9.06e-01



Evaluating how well 122_sigma-diff genes are linked to bottom_50_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff	bottom_50_from_93_diffusions	0.52	-0.42	-0.38	-0.29	0.42
bottom_50_from_93_diffusions	122_sigma-diff	0.50	-1.19	-1.49	-1.10	0.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff	bottom_50_from_93_diffusions	0.00	-0.55	-0.71	-0.62	-0.48
bottom_50_from_93_diffusions	122_sigma-diff	0.01	-0.42	-0.45	-0.36	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff	118	116	;RFPL2
bottom_50_from_93_diffusions	50	50