Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma_diff Exclusive	top_25_from_93_diffusions	8.13e-07	1.03e-05	3.71e-08	5.94e-13
top_25_from_93_diffusions Exclusive	82_male_sigma_diff	2.25e-01	2.12e-02	9.30e-07	6.69e-04
82_male_sigma_diff Exclusive	top_25_from_93_diffusions Exclusive	8.20e-06	6.68e-05	2.13e-06	1.40e-11
top_25_from_93_diffusions Exclusive	82_male_sigma_diff Exclusive	7.09e-01	1.95e-02	3.61e-06	7.11e-03
82_male_sigma_diff Exclusive	Overlap	5.00e-03	7.96e-02	5.00e-03	1.98e-04
top_25_from_93_diffusions Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	3.94e-04	4.58e-04	1.73e-12	6.59e-06



Evaluating how well 82_male_sigma_diff genes are linked to top_25_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	top_25_from_93_diffusions	0.92	3.84	6.54	4.36	7.28
top_25_from_93_diffusions Exclusive	82_male_sigma_diff	0.59	2.22	2.80	3.26	3.15
82_male_sigma_diff Exclusive	top_25_from_93_diffusions Exclusive	0.92	3.76	5.91	3.27	6.88
top_25_from_93_diffusions Exclusive	82_male_sigma_diff Exclusive	0.58	1.74	2.67	2.87	2.21
82_male_sigma_diff Exclusive	Overlap	0.97	2.72	2.57	2.08	2.80
top_25_from_93_diffusions Exclusive	Overlap	1.00	3.11	2.13	2.83	3.09
Overlap	Exclusives	0.64	2.51	4.51	2.78	4.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma_diff Exclusive	top_25_from_93_diffusions	0.01	12.16	16.17	15.78	3.05
top_25_from_93_diffusions Exclusive	82_male_sigma_diff	0.03	30.12	34.04	40.93	36.51
82_male_sigma_diff Exclusive	top_25_from_93_diffusions Exclusive	0.01	11.63	16.63	6.82	2.37
top_25_from_93_diffusions Exclusive	82_male_sigma_diff Exclusive	0.02	19.67	34.20	30.91	24.82
82_male_sigma_diff Exclusive	Overlap	0.00	7.68	10.07	6.00	6.17
top_25_from_93_diffusions Exclusive	Overlap	0.10	462.44	120.69	354.04	270.33
Overlap	Exclusives	0.06	51.74	89.78	47.41	79.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma_diff Exclusive	77	76	
top_25_from_93_diffusions Exclusive	22	22	
Overlap	3	3