Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 69_male_sigma_diff Exclusive top_25_from_93_diffusions 6.39e-07 1.49e-08 2.20e-08 2.96e-11 top_25_from_93_diffusions Exclusive 69_male_sigma_diff 4.18e-01 5.39e-01 2.03e-03 1.29e-01 69_male_sigma_diff Exclusive top_25_from_93_diffusions Exclusive 2.04e-05 4.30e-08 3.18e-07 1.35e-09 top_25_from_93_diffusions Exclusive 69_male_sigma_diff Exclusive 6.91e-01 6.44e-01 2.83e-03 1.53e-01 69_male_sigma_diff Exclusive Overlap 3.72e-02 5.74e-01 2.49e-02 2.07e-03 top_25_from_93_diffusions Exclusive Overlap 9.85e-05 9.85e-05 9.85e-05 9.85e-05 Overlap Exclusives 4.77e-04 2.79e-04 4.62e-12 6.04e-06 Evaluating how well 69_male_sigma_diff genes are linked to top_25_from_93_diffusions genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 69_male_sigma_diff Exclusive top_25_from_93_diffusions 0.89 2.35 6.62 3.01 6.79 top_25_from_93_diffusions Exclusive 69_male_sigma_diff 0.56 2.29 0.98 1.72 1.63 69_male_sigma_diff Exclusive top_25_from_93_diffusions Exclusive 0.88 2.18 5.88 3.50 6.53 top_25_from_93_diffusions Exclusive 69_male_sigma_diff Exclusive 0.54 1.78 0.74 1.61 1.22 69_male_sigma_diff Exclusive Overlap 0.97 1.64 1.55 1.86 2.41 top_25_from_93_diffusions Exclusive Overlap 1.00 2.61 1.54 2.41 2.49 Overlap Exclusives 0.65 2.89 4.84 2.89 5.70 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 69_male_sigma_diff Exclusive top_25_from_93_diffusions 0.01 3.49 20.64 7.04 12.51 top_25_from_93_diffusions Exclusive 69_male_sigma_diff 0.02 38.76 17.19 11.00 34.08 69_male_sigma_diff Exclusive top_25_from_93_diffusions Exclusive 0.01 2.39 19.65 6.82 13.93 top_25_from_93_diffusions Exclusive 69_male_sigma_diff Exclusive 0.02 28.05 18.88 24.36 31.85 69_male_sigma_diff Exclusive Overlap 0.00 4.71 2.15 3.36 11.14 top_25_from_93_diffusions Exclusive Overlap 0.06 56.60 65.60 322.47 135.64 Overlap Exclusives 0.04 17.04 58.62 39.93 28.41 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 69_male_sigma_diff Exclusive 65 62 ;RFPL2;RAB6D top_25_from_93_diffusions Exclusive 23 23 Overlap 2 2