Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_male_sigma_diff Exclusive	50_from_93_diffusions	4.12e-05	1.41e-06	2.87e-06	6.80e-10
50_from_93_diffusions Exclusive	69_male_sigma_diff	4.51e-01	9.39e-01	1.58e-01	2.41e-01
69_male_sigma_diff Exclusive	50_from_93_diffusions Exclusive	9.21e-05	6.51e-06	6.71e-06	3.04e-09
50_from_93_diffusions Exclusive	69_male_sigma_diff Exclusive	8.26e-01	9.70e-01	3.00e-01	5.80e-01
69_male_sigma_diff Exclusive	Overlap	2.28e-02	5.55e-01	1.18e-02	4.43e-03
50_from_93_diffusions Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.74e-09	2.63e-10	2.92e-21	1.90e-12



Evaluating how well 69_male_sigma_diff genes are linked to 50_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_male_sigma_diff Exclusive	50_from_93_diffusions	0.79	2.17	6.34	2.92	7.33
50_from_93_diffusions Exclusive	69_male_sigma_diff	0.54	1.42	0.44	0.73	1.46
69_male_sigma_diff Exclusive	50_from_93_diffusions Exclusive	0.78	2.19	5.35	2.87	6.80
50_from_93_diffusions Exclusive	69_male_sigma_diff Exclusive	0.53	0.93	0.42	0.56	0.81
69_male_sigma_diff Exclusive	Overlap	0.97	1.60	1.77	2.23	2.17
50_from_93_diffusions Exclusive	Overlap	1.00	2.32	2.03	2.66	2.20
Overlap	Exclusives	0.71	4.97	7.28	3.04	8.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_male_sigma_diff Exclusive	50_from_93_diffusions	0.01	5.60	15.16	5.90	3.96
50_from_93_diffusions Exclusive	69_male_sigma_diff	0.03	47.77	27.39	43.74	39.30
69_male_sigma_diff Exclusive	50_from_93_diffusions Exclusive	0.01	5.16	13.63	6.72	15.51
50_from_93_diffusions Exclusive	69_male_sigma_diff Exclusive	0.02	22.40	22.10	25.25	28.01
69_male_sigma_diff Exclusive	Overlap	0.00	4.52	2.89	5.84	1.09
50_from_93_diffusions Exclusive	Overlap	0.12	133.03	448.40	684.86	286.07
Overlap	Exclusives	0.07	40.65	101.06	44.44	57.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_male_sigma_diff Exclusive	65	62	;RFPL2;RAB6D
50_from_93_diffusions Exclusive	48	48	
Overlap	2	2