Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_male_sigma_diff	bottom_50_from_93_diffusions	8.44e-01	5.69e-01	2.50e-01	2.33e-01
bottom_50_from_93_diffusions	69_male_sigma_diff	8.39e-02	1.05e-01	1.50e-01	3.00e-01



Evaluating how well 69_male_sigma_diff genes are linked to bottom_50_from_93_diffusions genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_male_sigma_diff	bottom_50_from_93_diffusions	0.54	0.12	0.32	0.27	0.81
bottom_50_from_93_diffusions	69_male_sigma_diff	0.49	-0.97	-1.08	-1.05	-0.41

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_male_sigma_diff	bottom_50_from_93_diffusions	0.00	-0.42	-0.10	-0.27	-0.19
bottom_50_from_93_diffusions	69_male_sigma_diff	0.00	0.33	0.10	-0.05	0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_male_sigma_diff	67	64	;RAB6D;RFPL2
bottom_50_from_93_diffusions	50	50