Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CAND Exclusive	UKB	7.44e-01	6.31e-01	8.65e-02	7.99e-01
UKB Exclusive	CAND	7.80e-01	3.01e-01	6.19e-01	6.08e-02
CAND Exclusive	UKB Exclusive	5.82e-01	5.97e-01	7.70e-02	6.11e-01
UKB Exclusive	CAND Exclusive	6.52e-01	3.83e-01	7.64e-01	5.81e-02
CAND Exclusive	Overlap	1.63e-01	4.03e-01	2.18e-01	4.88e-01
UKB Exclusive	Overlap	6.61e-01	6.93e-01	6.27e-01	6.27e-01
Overlap	Exclusives	3.62e-06	5.00e-01	6.86e-15	3.24e-01



Evaluating how well CAND genes are linked to UKB genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND Exclusive	UKB	0.49	-0.59	-0.27	-0.42	-0.23
UKB Exclusive	CAND	0.46	-0.24	-0.97	-0.40	-1.74
CAND Exclusive	UKB Exclusive	0.49	-0.90	-0.47	-0.54	-0.42
UKB Exclusive	CAND Exclusive	0.46	-0.26	-0.82	-0.56	-1.66
CAND Exclusive	Overlap	0.59	1.40	0.58	1.10	0.56
UKB Exclusive	Overlap	0.32	-0.10	-0.73	-0.30	-0.78
Overlap	Exclusives	0.48	-0.95	-0.96	-0.47	-1.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND Exclusive	UKB	0.01	-0.44	0.56	0.06	-0.16
UKB Exclusive	CAND	0.01	0.67	0.31	0.34	-0.59
CAND Exclusive	UKB Exclusive	0.01	-0.72	0.31	-0.03	-0.21
UKB Exclusive	CAND Exclusive	0.01	0.62	0.35	0.09	-0.46
CAND Exclusive	Overlap	0.00	0.15	-0.18	0.20	-0.23
UKB Exclusive	Overlap	0.00	-0.29	-0.42	-0.34	-0.61
Overlap	Exclusives	0.02	-0.71	-0.45	-0.38	-0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CAND Exclusive	171	171	
UKB Exclusive	203	201	C17orf113;KDM5D
Overlap	2	2