Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CAND 101 AD	GS_tier1	5.74e-01	9.34e-01	4.26e-01	3.55e-01
GS_tier1	CAND 101 AD	4.70e-01	9.03e-01	7.21e-01	8.50e-01



Evaluating how well CAND 101 AD genes are linked to GS_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND 101 AD	GS_tier1	0.57	-0.35	-0.27	-0.21	1.33
GS_tier1	CAND 101 AD	0.48	0.35	0.21	0.22	-0.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND 101 AD	GS_tier1	0.00	-0.40	-0.56	-0.50	-0.14
GS_tier1	CAND 101 AD	0.00	-0.36	-0.28	-0.35	-0.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CAND 101 AD	101	101	
GS_tier1	31	30	MS4A