Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
CAND_101AD	GS_tier2	7.64e-01	7.14e-01	1.37e-01	2.37e-01
GS_tier2	CAND_101AD	7.98e-01	8.08e-01	4.10e-03	6.96e-01



Evaluating how well CAND_101AD genes are linked to GS_tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND_101AD	GS_tier2	0.58	-0.06	-0.00	-0.56	2.06
GS_tier2	CAND_101AD	0.48	0.76	0.06	0.30	-0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
CAND_101AD	GS_tier2	0.00	-0.01	0.06	-0.47	1.74
GS_tier2	CAND_101AD	0.00	-0.11	-0.34	-0.38	-0.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
CAND_101AD	101	101	
GS_tier2	46	43	IGH;TNSF12;TNSF13