Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma-diff	25-GS	9.89e-01	8.15e-01	7.50e-01	4.93e-01
25-GS	82_male_sigma-diff	8.42e-02	1.71e-01	7.38e-02	7.64e-02



Evaluating how well 82_male_sigma-diff genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff	25-GS	0.57	0.52	0.93	0.82	1.30
25-GS	82_male_sigma-diff	0.57	2.12	1.91	1.99	2.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff	25-GS	0.00	0.45	0.44	0.61	0.22
25-GS	82_male_sigma-diff	0.00	0.75	0.05	1.07	0.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma-diff	79	79	
25-GS	23	21	AC074212.3;APT8B4