Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff	46-GS	3.98e-01	3.34e-02	3.84e-02	3.51e-03
46-GS	69_female_sigma-diff	4.20e-01	6.70e-01	2.06e-01	4.84e-01



Evaluating how well 69_female_sigma-diff genes are linked to 46-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	46-GS	0.66	1.03	2.60	1.90	4.57
46-GS	69_female_sigma-diff	0.53	0.85	0.57	0.51	0.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	46-GS	0.01	1.94	4.79	3.61	0.94
46-GS	69_female_sigma-diff	0.02	20.55	14.50	24.89	26.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff	67	64	;RAB6D;RFPL2
46-GS	46	43	TNSF13;TNSF12;IGH