Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff	25-GS	3.11e-01	4.71e-02	6.38e-02	1.63e-03
25-GS	69_female_sigma-diff	4.91e-01	8.19e-01	1.58e-01	4.70e-01



Evaluating how well 69_female_sigma-diff genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	25-GS	0.66	1.18	2.11	1.74	3.81
25-GS	69_female_sigma-diff	0.53	0.67	0.09	0.65	0.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	25-GS	0.01	2.42	3.49	2.30	3.71
25-GS	69_female_sigma-diff	0.02	25.17	18.59	30.21	29.90

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff	67	64	;RAB6D;RFPL2
25-GS	46	43	TNSF12;TNSF13;IGH