Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_sigma-diff Exclusive	22-GS	1.78e-14	1.96e-14	3.57e-17	3.67e-24
22-GS Exclusive	122_sigma-diff	1.49e-02	4.85e-04	3.82e-12	1.18e-06
122_sigma-diff Exclusive	22-GS Exclusive	6.59e-11	3.27e-12	1.88e-13	4.99e-20
22-GS Exclusive	122_sigma-diff Exclusive	1.88e-02	8.64e-04	1.38e-11	9.72e-06
122_sigma-diff Exclusive	Overlap	2.31e-05	9.82e-03	6.40e-08	9.05e-07
22-GS Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	9.14e-09
Overlap	Exclusives	6.74e-04	1.99e-03	2.90e-11	2.43e-04



Evaluating how well 122_sigma-diff genes are linked to 22-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	22-GS	0.98	4.58	6.44	4.28	9.06
22-GS Exclusive	122_sigma-diff	0.64	4.86	5.09	4.67	5.73
122_sigma-diff Exclusive	22-GS Exclusive	0.98	5.07	7.18	4.10	7.09
22-GS Exclusive	122_sigma-diff Exclusive	0.63	5.21	4.74	4.89	4.85
122_sigma-diff Exclusive	Overlap	0.99	2.53	3.01	2.34	3.34
22-GS Exclusive	Overlap	1.00	3.42	3.12	2.75	3.73
Overlap	Exclusives	0.62	1.94	3.51	2.06	5.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_sigma-diff Exclusive	22-GS	0.05	22.74	41.00	32.79	9.68
22-GS Exclusive	122_sigma-diff	0.03	24.67	30.50	35.92	38.75
122_sigma-diff Exclusive	22-GS Exclusive	0.03	21.58	36.57	18.97	18.07
22-GS Exclusive	122_sigma-diff Exclusive	0.02	24.76	20.69	19.78	23.34
122_sigma-diff Exclusive	Overlap	0.02	18.63	29.13	38.10	12.42
22-GS Exclusive	Overlap	0.10	268.02	199.93	216.54	223.65
Overlap	Exclusives	0.06	38.42	66.62	47.49	74.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_sigma-diff Exclusive	114	112	;RFPL2
22-GS Exclusive	18	18	
Overlap	4	4