Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
82_male_sigma-diff Exclusive	22-GS	1.27e-05	6.82e-05	7.88e-07	1.55e-13
22-GS Exclusive	82_male_sigma-diff	1.72e-01	6.84e-02	1.29e-05	1.55e-02
82_male_sigma-diff Exclusive	22-GS Exclusive	7.57e-05	2.35e-04	1.34e-05	2.97e-11
22-GS Exclusive	82_male_sigma-diff Exclusive	4.90e-01	1.40e-01	3.68e-05	3.61e-02
82_male_sigma-diff Exclusive	Overlap	3.98e-03	8.22e-02	1.43e-03	1.13e-03
22-GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.79e-03	1.73e-03	1.78e-11	6.59e-05



Evaluating how well 82_male_sigma-diff genes are linked to 22-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff Exclusive	22-GS	0.93	3.49	6.00	3.12	7.82
22-GS Exclusive	82_male_sigma-diff	0.58	1.72	1.90	2.03	2.54
82_male_sigma-diff Exclusive	22-GS Exclusive	0.92	3.84	5.69	3.64	6.03
22-GS Exclusive	82_male_sigma-diff Exclusive	0.56	1.30	1.60	1.65	1.88
82_male_sigma-diff Exclusive	Overlap	0.97	2.61	2.25	2.70	2.74
22-GS Exclusive	Overlap	1.00	3.36	2.22	2.56	3.01
Overlap	Exclusives	0.63	1.93	3.67	2.53	4.49

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
82_male_sigma-diff Exclusive	22-GS	0.01	8.01	15.82	8.25	19.16
22-GS Exclusive	82_male_sigma-diff	0.03	33.95	35.50	40.65	30.32
82_male_sigma-diff Exclusive	22-GS Exclusive	0.01	9.57	15.75	12.42	7.43
22-GS Exclusive	82_male_sigma-diff Exclusive	0.02	28.27	21.99	24.33	30.55
82_male_sigma-diff Exclusive	Overlap	0.00	8.80	8.15	4.41	0.94
22-GS Exclusive	Overlap	0.10	448.01	164.30	390.55	296.25
Overlap	Exclusives	0.06	47.21	88.27	27.37	84.41

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
82_male_sigma-diff Exclusive	77	76	
22-GS Exclusive	19	19	
Overlap	3	3