Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff Exclusive	22-GS	5.11e-06	2.79e-07	8.64e-08	1.44e-10
22-GS Exclusive	69_female_sigma-diff	3.60e-01	7.59e-01	5.60e-04	1.48e-01
69_female_sigma-diff Exclusive	22-GS Exclusive	4.47e-05	5.20e-07	9.59e-07	8.42e-09
22-GS Exclusive	69_female_sigma-diff Exclusive	6.87e-01	7.84e-01	4.14e-04	4.67e-01
69_female_sigma-diff Exclusive	Overlap	1.68e-02	5.55e-01	1.68e-02	4.43e-03
22-GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.77e-03	1.17e-03	1.46e-11	6.88e-05



Evaluating how well 69_female_sigma-diff genes are linked to 22-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	22-GS	0.90	2.24	5.68	3.71	6.96
22-GS Exclusive	69_female_sigma-diff	0.55	2.28	1.10	1.55	1.62
69_female_sigma-diff Exclusive	22-GS Exclusive	0.90	2.31	5.27	3.46	5.45
22-GS Exclusive	69_female_sigma-diff Exclusive	0.54	1.66	0.94	1.24	1.02
69_female_sigma-diff Exclusive	Overlap	0.97	1.74	1.99	2.10	2.47
22-GS Exclusive	Overlap	1.00	3.08	1.58	2.13	2.60
Overlap	Exclusives	0.64	2.67	4.36	2.73	4.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff Exclusive	22-GS	0.01	4.15	17.87	11.19	19.11
22-GS Exclusive	69_female_sigma-diff	0.02	11.93	17.33	9.17	33.95
69_female_sigma-diff Exclusive	22-GS Exclusive	0.01	4.12	18.58	8.86	20.11
22-GS Exclusive	69_female_sigma-diff Exclusive	0.02	9.64	13.64	22.34	25.65
69_female_sigma-diff Exclusive	Overlap	0.00	3.16	3.62	5.27	7.06
22-GS Exclusive	Overlap	0.06	268.21	50.14	96.12	266.82
Overlap	Exclusives	0.04	17.03	48.31	37.79	23.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff Exclusive	65	62	;RAB6D;RFPL2
22-GS Exclusive	20	20	
Overlap	2	2