Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
69_female_sigma-diff	25-GS	6.66e-01	6.88e-01	5.31e-01	5.27e-01
25-GS	69_female_sigma-diff	6.74e-01	9.23e-01	5.35e-01	6.18e-01



Evaluating how well 69_female_sigma-diff genes are linked to 25-GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	25-GS	0.54	0.29	0.28	0.14	0.54
25-GS	69_female_sigma-diff	0.53	0.91	0.48	0.86	1.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
69_female_sigma-diff	25-GS	0.00	-0.38	-0.21	-0.34	-0.27
25-GS	69_female_sigma-diff	0.00	-0.10	-0.29	-0.10	-0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
69_female_sigma-diff	66	64	RAB6D;RFPL2
25-GS	23	21	AC074212.3;APT8B4